Scientific Publications - Genalyte

High-Q optical sensors for chemical and biological analysis

by Matthew Luchansky | Nov 23, 2011 | 2011 News, Publications, Scientific Publications

Introduction Optical sensors represent a vitally important class of analytical tools that have been used to provide chemical information ranging from analyte concentration and binding kinetics to microscopic imaging and molecular structure. Optical sensors utilize a...

Label-free virus detection using silicon photonic microring resonators

by Melinda McClellan | Nov 11, 2011 | 2011 News, Publications, Scientific Publications

Abstract Viruses represent a continual threat to humans through a number of mechanisms, which include disease, bioterrorism, and destruction of both plant and animal food resources. Many contemporary techniques used for the detection of viruses and viral infections...

Isothermal Discrimination of Single-Nucleotide Polymorphisms via Real-Time Kinetic Desorption and Label-Free Detection of DNA Using Silicon Photonic Microring Resonator Arrays

by ACS - Abraham Qavi | Aug 12, 2011 | 2011 News, Publications, Scientific Publications

Abstract We report a sensitive, label-free method for detecting single-stranded DNA and discriminating between single nucleotide polymorphisms (SNPs) using arrays of silicon photonic microring resonators. In only a 10 min assay, DNA is detected at subpicomole levels...

Anti-DNA:RNA Antibodies and Silicon Photonic Microring Resonator Arrays Enable the Ultrasensitive, Multiplexed Detection of microRNAs

by Abraham Qavi | Jun 29, 2011 | 2011 News, Publications, Scientific Publications

Abstract In this paper, we present a method for the ultrasensitive detection of microRNAs (miRNAs) utilizing an antibody that specifically recognizes DNA:RNA heteroduplexes, using a silicon photonic microring resonator array transduction platform. Microring resonator...

Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads

by Matthew Luchansky | Jun 21, 2011 | Scientific Publications

Abstract We demonstrate a three-step assay on a silicon photonic microring resonator-based detection platform that enables the quantitation of the cardiac biomarker C-reactive protein (CRP) over a dynamic range spanning six orders of magnitude. Using antibody-modified...

New Multiparameter Bioanalytical Technologies for Applications in Personalized Medicine, Drug Discovery, and Fundamental Biology

by Ryan Bailey | Jun 2, 2011 | Scientific Publications

Abstract The ability to determine expression levels of multiple genetic and/or proteomic signatures simultaneously from the same sample volume is of tremendous importance in a wide range of biomedical applications including disease diagnostics, drug discovery, and...

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